Word 1:Prostate (PRAHS tayt)
Meaning 1: A gland found in all male mammals.
Example Sentence: Prostate cancer if detected early is easily treatable.

Word 2: Prostrate (PRAHS trayt)
Meaning 1: Lying with face down and arms stretched out.
Example Sentence: The man lay on the ground prostrate praying to God.
Meaning 2: Completely overcome or helpless.
Example Sentence: The woman was prostrate with grief and had no will to fight the circumstances.

Example Sentence using both words:
The man with the enlarged prostate lay prostrate before the doctor.